How Low Dose Naltrexone Works For Autoimmune Diseases

How LDN Works


To begin to comprehend how Low Dose Naltrexone (LDN) works it is necessary for you to know about Endorphins.

Endorphins are the body's natural feel-good opioids.


Endorphins are neurotransmitters, (chemicals) that pass along signals from one neuron to the next. 


Endorphins are produced as a response to certain stimuli.

More Endorphins are produced during times of stress, fear or pain.

Endorphins originate in numerous parts of your body.


Endorphins are produced in:

  • The pituitary gland
  • The spinal cord
  • The nervous 
  • Other parts of your brain nervous system

Endorphins interact mainly with receptors in cells found in regions of the brain responsible for blocking pain and controlling emotion.

Most cells in the body produce Endorphins.

It is theorized that low levels of natural Endorphins and immune system disorders are associated.

Hence, low levels of Endorphins may lead to MS, Chronic Fatigue Syndrome, RA, ALS and a host of other autoimmune diseases.


Dr. Bernard Bihari was a New York City Board-certified specialist in Neurology and Psychiatry.

In 1985, Doctor Bihari discovered the positive effects of Low Dose Naltrexone. 

Dr. Bihari found that a low dose of Naltrexone taken at bedtime enhanced his patient's response to the HIV virus.

In 1985 Dr. Bihari believed the 3 mg of Naltrexone was the best dose for the body's immune system. 

However, today it is now thought a person should take between 3.5 mg- of Naltrexone.

The effects of Low Dose Naltrexone vary from person to person. 


When you take low dose naltrexone (usually, 3.5-5 mg) in the evening the low dose naltrexone blocks OGF receptors for a few hours.

The blockage of the OGF receptors tricks the body into the release of more Endocrines.

The result of elevated Endorphins is referred to as the, "rebound effect."

Usually, the rebound effect from low dose naltrexone lasts for a twenty-four hour period.

However, the rebound effects of low dose naltrexone can vary individually.

An individual can only utilize the "rebound effect" with the daily consumption of low dose naltrexone.


The standard naltrexone pill dosage of 50mg or the use of timed-release Naltrexone pill will result in the complete blockade of the OGF receptors.

If the Opioid Growth Receptors become completely blocked, the "rebound effect" will not occur.

The, "Rebound Effect" from Low Dose Naltrexone may be able to help people with autoimmune diseases.


People with autoimmune diseases have found that low dose naltrexone is beneficial for:

  • Low dose naltrexone for depression
  • Low dose naltrexone for pain
  • LDN for MS
  • Low dose naltrexone anxiety
  • Low dose naltrexone helps rheumatoid arthritis
  • LDN helps thyroid conditions
  • Low dose naltrexone for nerve pain 

There are dozens of autoimmune diseases and cancer where LDN has shown positive results.

The book Honest Medicine: Effective, Time-Tested, Inexpensive Treatments for Life-Threatening Diseases by Julia E. Schopick may help you to better understand how Low Dose Naltrexone Works. 


Side effects of low dose naltrexone in clinical trials have shown vivid dream and sleep disturbances in some patients. 

These patients were given low dose naltrexone to take at bedtime. 

The low dose naltrexone side effects in these patients usually disappeared in the first weeks of taking ldn.

If low dose naltrexone side effects persist then low dose naltrexone may be taken in the morning.


You need a doctor's prescription for Low Dose Naltrexone (LDN).

Low dose naltrexone is an off-label prescription so many doctors are not familiar with the benefits of LDN.

If is not wise to buy LDN online from a random website. 

The LDN from an unreliable source may be counterfeit and cause you to have harmful side effects. 

The LDN Trust Organization provides a list of pharmacists from around the world.

Here is their LND Pharmacists webpage. 





You can learn more about Low Dose Naltrexone on the HypoGal Website.

On a personal note, I have used Low Dose Naltrexone for approximately two years.

Low Dose Naltrexone has not been my, "Magic Pill" but I definitely notice an increase in my energy level.

Low Dose Naltrexone has given me a new baseline. 

If you are interested in finding out if Low Dose Naltrexone may help you then I would strongly recommend that you review the LDN Trust Organization website. 

I have read that it definitely does matter where you purchase your Low Dose Naltrexone.


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